Genentech serves as whipping boy again on Avastin/Lucentis

The New York Times headline Genentech Offers Secret Rebates for Eye Drug slams the company for offering physicians incentives to use Lucentis for wet age related macular degeneration instead of Avastin. They talk about a “confidential document,” find a doctor to accuse Genentech of “bribery” for running the program and quote a Senator to complain that Medicare is being hurt. As far as I can tell the rebate program isn’t seem any more secret than any other rebate program –it’s not as though these are typically publicized– the doctor is exaggerating, and the Senator doesn’t realize that the absurdly low price of Avastin when used for ophthalmology is a real threat to further progress in the field.

I’m sympathetic to Genentech, for reasons I explained earlier this year (Avastin instead of Lucentis: Something’s not quite right):

Avastin is a highly-effective anti-cancer drug. Lucentis is basically the same drug, but it’s indicated for an ophthalmic condition: wet age-related macular degeneration. Since Lucentis is injected in the eye only a little bit is needed. Some enterprising doctors and pharmacists figured out they could split up one Avastin dose into lots of Lucentis doses. Instead of $2000 or so for a Lucentis treatment they have an Avastin equivalent for less than $100 –maybe as low as $20.

The situation has caused Genentech a lot of grief. Their revenues have suffered, they’ve taken a lot of hits in the press and from eye doctors, and the FDA has started holding Avastin production facilities to stricter standards usually reserved for ophthalmic products. The company is in a tricky situation and has had to fall back on the notion that Lucentis has gone through clinical trials for wet AMD while Avastin hasn’t. That’s a weak argument and is undermined by a new Kaiser study showing equivalence.

In the short run only Genentech loses out. Patients get a much less expensive drug and insurance premiums are a little lower than they would be otherwise.

But it’s also shown the world that the price point for a wet AMD treatment is $20 or so. Now who on earth is going to bother developing a new treatment for wet AMD? I’ve already seen situations where companies chose to drop development of early stage compounds in this therapeutic area because they are afraid they can’t make money.

The problem is really the way that drugs are priced. Avastin is priced by volume, but really what patients are getting is a treatment for cancer that’s worth a certain amount of money, regardless of the amount of physical product used. In the past I’ve proposed a software licensing model for drugs. Despite the challenges of implementation I still think it’s a good idea.

November 5, 2010

One thought on “Genentech serves as whipping boy again on Avastin/Lucentis”

  1. Although, I agree with your discussion. I still feel that as professionals instead of focusing on the ‘business’ aspect of healthcare, we should direct our efforts in making our clinical skills more sound. Below is a nice website, where you can start.
    1. Central searchable repository of a pharmacists ‘curb-side’ notes.
    2. Transition between hospital and retail settings, your notes can transition with you, not your job!
    3. For access from anywhere, when I do not have direct access to my references/websites.
    4. For the Pharmacist, BY the Pharmacist.

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