Category: Pharma

Another vaccine for a non-fatal condition

published date
October 5th, 2006 by

Another vaccine for a non-fatal condition

I’ve been posting recently about the trend toward vaccines for non-fatal conditions. See here and here. Now it looks like there’s another one on the horizon, this time for hay fever. From MedPage Today:

An investigational hay fever vaccine it appears to ease the symptoms of ragweed allergy for up to two years after a course of only six injections… In a small, prospective randomized study, the vaccine reduced hay fever symptoms by about 60% compared with placebo, reported Peter Creticos, M.D., of Johns Hopkins, and colleagues, in the Oct. 5 issue of the New England Journal of Medicine. The effect lasted through two allergy seasons.

More from Wal-Mart?

published date
October 4th, 2006 by

More from Wal-Mart?

Wal-Mart is due to make a new announcement tomorrow in Florida with Gov Jeb Bush in attendance. Something new on the health care front? We’ll see.

Make way for Retrodal, Preprexa and Preoquel

published date
October 3rd, 2006 by

Make way for Retrodal, Preprexa and Preoquel

J&J is smarter than it sometimes lets on. As reported earlier (Clarinex, Nexium, Nexperdal?), the company isn’t testing its ‘new and improved’ anti-psychotic, paliperidone against its soon-to-go-generic blockbuster Risperdal, because despite the hype there’s no reason to think paliperidone is better.

They’re also not testing paliperidone against older drugs, and here’s one reason why. From The Washington Post (In Antipsychotics, Newer Isn’t Better), subtitled –in an apparent attempt to be even more dramatic than the New York Times— “Drug Find Shocks Researchers” says:

Schizophrenia patients do as well, or perhaps even better, on older psychiatric drugs compared with newer and far costlier medications, according to a study published yesterday that overturns conventional wisdom about antipsychotic drugs, which cost the United States $10 billion a year.

The results are causing consternation. The researchers who conducted the trial were so certain they would find exactly the opposite that they went back to make sure the research data had not been recorded backward…

“The claims of superiority for the [newer drugs] were greatly exaggerated,” wrote Columbia University psychiatrist Jeffrey Lieberman. “This may have been encouraged by an overly expectant community of clinicians and patients eager to believe in the power of new medications. At the same time, the aggressive marketing of these drugs may have contributed to this enhanced perception of their effectiveness in the absence of empirical information.”

How long until someone dresses up one of the old drugs in a new formulation and demonstrates superiority over the newer classes?

Move over Risperdal, Zyprexa, and Seroquel. Make way for Retrodal, Preprexa and Preoquel!

And yes, Virginia it turns out there already is a Desperal, but still no Nexperdal or Ripofferdal.

Clarinex, Nexium, Nexperdal?

published date
September 29th, 2006 by

Clarinex, Nexium, Nexperdal?

J&J is stealing a play from AstraZeneca and Schering-Plough. AZ couldn’t come up with a worthy successor to Prilosec, so when the drug went off patent the company introduced the infamous Nexium, which is the substance the body turns Prilosec into. Basically you get Nexium when you swallow Prilosec, yet Nexium managed to become a multibillion product. Clarinex is just a tiny tweak on Claritin, introduced when Claritin’s patent expired.

Now J&J is faced with the expiration of its blockbuster for schizophrenia, Risperdal. When a patient takes Risperdal the body converts it to paliperidone. So just like AZ, J&J is going to market paliperidone as the next thing. J&J claims paliperidone is better than Risperdal, but that’s doubtful. From the Wall Street Journal:

The research backing J&J’s claims for paliperidone seems a little thin. Clinical tests, involving 1600 patients, pitted it against a sugar pill, not Risperdal or other antipsychotic drugs…

“They can’t claim its better than risperidone [Risperdal’s generic name] because they didn’t do the comparison,” said [Duke psychiatry professor] P. Murali Doraiswamy.

Basically, J&J is proving that paliperidone is better than nothing. That’s not a very high standard.

Meanwhile doctors, health plans, and patients haven’t set a very high standard either. Doctors continue to accept Nexium samples and prescribe the drug, most payers still have it on formulary, and patients continue to insist on the purple pill. Time to wise up!

J&J hasn’t picked a brand name for paliperidone yet. Here are a few suggestions:

  • Nexperdal
  • Ripofferdal
  • Desperal